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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T13345 | Wnt pathway activator 2 | Others , Wnt/beta-catenin | |
Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM. | |||
T17256 | Wnt pathway activator 1 | Wnt/beta-catenin | |
Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM. Wnt pathway activator 1 is a potent Wnt activator for the treatment of androgenetic alopecia (AGA). | |||
T77502 | Wnt pathway inhibitor 3 | Wnt/beta-catenin , Adenylyl cyclase | |
Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studies to ameliorate osteoarthritis in a mouse model of experimenta... | |||
T77716 | Wnt pathway inhibitor 4 | Antibacterial | |
Wnt pathway inhibitor 4 is a small molecule antimicrobial agent with antibacterial and antiproliferative activity against cancer cells. | |||
T9810 | TNIK-IN-5 | Wnt/beta-catenin | |
TNIK-IN-5 is an potent TNIK inhibitor (IC50= 0.05 μM). TNIK-IN-5 potently inhibits Wnt signaling in intact cells. TNIK-IN-5 exhibits excellent in vitro anti-colorectal cancer activity. | |||
T12885 | SGC-AAK1-1 | AAK1 (AP2 associated kinase 1) | |
SGC-AAK1-1 is a potent and selective inhibitor of AAK1 (AP2 associated kinase 1) (IC50 of 270 nM and a Ki of 9 nM),and is a chemical probe. | |||
T38519 | YB-0158 | Wnt pathway inhibitor 2,YB-0158 | |
YB-0158 (Wnt pathway inhibitor 2) is a powerful peptidomimetic compound that effectively targets colorectal cancer stem cells (CSCs) by disrupting the interaction between Sam68 and Src proteins. This compound acts as a r... | |||
T67866 | YW2036 | Wnt/beta-catenin | |
YW2036 is an inhibitor of Wnt signaling pathway. | |||
T27582 | ICRT-5 | iCRT 5,iCRT5 | Apoptosis , Wnt/beta-catenin |
iCRT-5 is a potent inhibitor of the Wnt pathway. iCRT-5 has antiproliferative activity, blocking Wnt/β-catenin expression and inducing apoptosis. iCRT-5 can be used in the study of multiple myeloma. | |||
T2651 | IWR-1 | IWR-1-endo,endo-IWR 1 | Wnt/beta-catenin |
IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM). | |||
T77780 | Zamaporvint | RXC004 | Others |
Zamaporvint (RXC004) is a selective, orally active and potent inhibitor of the Wnt pathway that acts on the membrane-bound fatty acyltransferase porcupine to block Wnt ligand palmitoylation, secretion, and pathway activa... | |||
T22884 | JW 67 | Wnt/beta-catenin | |
JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1. | |||
T15363 | FzM1.8 | Wnt/beta-catenin | |
FzM1.8 is an allosteric FZD4 agonist with a pEC50 of 6.4. FzM1.8 binds to FZD4, promotes TCF/LEF transcriptional activity in the absence of any WNT ligand, and activates the WNT/β-catenin pathway. | |||
T4486 | ICRT 14 | Wnt/beta-catenin | |
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity). | |||
T6989 | SKL2001 | Wnt/beta-catenin | |
SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction. | |||
T67884 | β-catenin modulator IIa-661 | Wnt/beta-catenin | |
β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity. | |||
T5636 | Adavivint | Adavivint (SM04690) | Wnt/beta-catenin |
Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor. | |||
T1957 | AZD2858 | GSK-3 | |
AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway. | |||
T3925 | Astragaloside I | Cyclosieversioside B,Astrasieversianin IV | Wnt/beta-catenin |
Astragaloside I (Cyclosieversioside B) is a natural product isolated from Astragalus membranaceus. It can stimulate osteoblast differentiation through the Wnt/β-catenin signaling pathway and can be used to study osteogen... | |||
T9151 | Teplinovivint | Wnt/beta-catenin | |
Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy research. |