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Search Results for " wnt pathway "

20

Compounds

Cat No. Product Name Synonyms Targets
T13345 Wnt pathway activator 2 Others , Wnt/beta-catenin
Wnt pathway activator 2 is a potent Wnt activator with an IC50 of 13 nM.
T17256 Wnt pathway activator 1 Wnt/beta-catenin
Wnt pathway activator 1 is a potent Wnt activator with an IC50 of 28-29 nM. Wnt pathway activator 1 is a potent Wnt activator for the treatment of androgenetic alopecia (AGA).
T77502 Wnt pathway inhibitor 3 Wnt/beta-catenin , Adenylyl cyclase
Wnt pathway inhibitor 3 is a potent AC1 inhibitor with an IC50 value of 45 nM.Wnt pathway inhibitor 3 has antiproliferative activity and can be used in studies to ameliorate osteoarthritis in a mouse model of experimenta...
T77716 Wnt pathway inhibitor 4 Antibacterial
Wnt pathway inhibitor 4 is a small molecule antimicrobial agent with antibacterial and antiproliferative activity against cancer cells.
T9810 TNIK-IN-5 Wnt/beta-catenin
TNIK-IN-5 is an potent TNIK inhibitor (IC50= 0.05 μM). TNIK-IN-5 potently inhibits Wnt signaling in intact cells. TNIK-IN-5 exhibits excellent in vitro anti-colorectal cancer activity.
T12885 SGC-AAK1-1 AAK1 (AP2 associated kinase 1)
SGC-AAK1-1 is a potent and selective inhibitor of AAK1 (AP2 associated kinase 1) (IC50 of 270 nM and a Ki of 9 nM),and is a chemical probe.
T38519 YB-0158 Wnt pathway inhibitor 2,YB-0158
YB-0158 (Wnt pathway inhibitor 2) is a powerful peptidomimetic compound that effectively targets colorectal cancer stem cells (CSCs) by disrupting the interaction between Sam68 and Src proteins. This compound acts as a r...
T67866 YW2036 Wnt/beta-catenin
YW2036 is an inhibitor of Wnt signaling pathway.
T27582 ICRT-5 iCRT 5,iCRT5 Apoptosis , Wnt/beta-catenin
iCRT-5 is a potent inhibitor of the Wnt pathway. iCRT-5 has antiproliferative activity, blocking Wnt/β-catenin expression and inducing apoptosis. iCRT-5 can be used in the study of multiple myeloma.
T2651 IWR-1 IWR-1-endo,endo-IWR 1 Wnt/beta-catenin
IWR-1 (IWR-1-endo), a Wnt pathway inhibitor, stabilizes the Axin destruction complex(EC50=0.2 uM).
T77780 Zamaporvint RXC004 Others
Zamaporvint (RXC004) is a selective, orally active and potent inhibitor of the Wnt pathway that acts on the membrane-bound fatty acyltransferase porcupine to block Wnt ligand palmitoylation, secretion, and pathway activa...
T22884 JW 67 Wnt/beta-catenin
JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1.
T15363 FzM1.8 Wnt/beta-catenin
FzM1.8 is an allosteric FZD4 agonist with a pEC50 of 6.4. FzM1.8 binds to FZD4, promotes TCF/LEF transcriptional activity in the absence of any WNT ligand, and activates the WNT/β-catenin pathway.
T4486 ICRT 14 Wnt/beta-catenin
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT)(IC50= 40.3 nM in assays of Wnt pathway activity).
T6989 SKL2001 Wnt/beta-catenin
SKL2001, an agonist of the Wnt/β-catenin pathway, can disrupt the Axin/β-catenin interaction.
T67884 β-catenin modulator IIa-661 Wnt/beta-catenin
β-catenin modulator IIa-661 is a small molecule inhibitor of the Wnt pathway with antitumour activity.
T5636 Adavivint Adavivint (SM04690) Wnt/beta-catenin
Adavivint (Adavivint (SM04690)) (SM04690) is a Wnt pathway inhibitor.
T1957 AZD2858 GSK-3
AZD2858 is a selective GSK-3 inhibitor, inhibiting tau phosphorylation at the S396 site and activating Wnt signaling pathway.
T3925 Astragaloside I Cyclosieversioside B,Astrasieversianin IV Wnt/beta-catenin
Astragaloside I (Cyclosieversioside B) is a natural product isolated from Astragalus membranaceus. It can stimulate osteoblast differentiation through the Wnt/β-catenin signaling pathway and can be used to study osteogen...
T9151 Teplinovivint Wnt/beta-catenin
Teplinovivint is a potent inhibitor of the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory properties with potential utility in tendinopathy research.
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